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KMID : 0043320100330030375
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Archives of Pharmacal Research
2010 Volume.33 No. 3 p.375 ~ p.380
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Cyclohexene, Diketopiperazine, Lactone and Phenol Derivatives from the Sea Fan-derived Fungi Nigrospora sp. PSU-F11 and PSU-F12
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Kirtikara Kanyawim
Rukachaisirikul Vatcharin
Khamthong Nanthaphong
Sukpondma Yaowapa
Phongpaichit Souwalak
Hutadilok-Towatana Nongporn
Graidist Potchanapond
Sakayaroj Jariya
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Abstract
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Nigrosporanenes A (1) and B (2), two new cylohexene derivatives, and tyrosol (3) were isolated from the sea fan-derived fungus Nigrospora sp. PSU-F11, whereas five known compounds: 4-hydroxybenzoic acid (4), aplysiopsene D (5), 3-isochromanone (6), (-)-drimenin (7) and diketopiperazine derivative (8), were obtained from the fungus Nigrospora sp. PSU-F12. Their structures were established by spectroscopic evidence. We also tested their cytotoxic (on African green monkey kidney fibroblast and breast cancer cells), antioxidant (in the DPPH assay), and antibacterial (against the standard Staphylococcus aureus ATCC 25923 and methicillinresistant S. aureus) activities.
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KEYWORD
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Nigrospora sp., Cyclohexenes, Lactones, Cytotoxic activity, Antioxidant activity, Antibacterial activity
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